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Chapter 8148questionnaire for measuring the impact of oral health on QoL.19 Other validated questionnaires commonly used in orthognathic studies are the Orthognathic Quality of Life Questionnaire (OQLQ) and the Short Form Health Survey (SF-36).15It is important to provide patients with realistic and accurate information prior to the start of orthognathic treatment. The temporary discomfort in the initial postoperative period, such as problems related to oral function, pain, numbness of the lower lip and chin, postoperative bleeding and swelling, should be explained to patients prior to the treatment, and they should also be given a realistic idea of the final facial appearance.20-22 This knowledge would lead to greater satisfaction after surgery.12,23,24The aim of this study was to evaluate the impact of orthognathic surgery on the QoL of patients with various dentofacial deformities in the immediate postoperative period and during at least 1 year of follow-up using the OHIP14 questionnaire. The hypothesis is that the QoL of patients with different dentofacial deformities improves with orthognathic surgery. This knowledge would be useful in improving preoperative, perioperative, and postoperative care and could lead to greater satisfaction for patients. Materials and MethodStudy design and ethical approvalThis prospective observational study was approved by the Medical Ethics Committee (METC W17_083#17.102) of Amsterdam University Medical Center (Amsterdam UMC, location AMC). It was granted a non-WMO status (Medical Research Involving Human Act).PatientsPatients were eligible for the study when they had facial skeletal malformations that required elective combined treatment with preoperative and postoperative orthodontic corrections and orthognathic surgery at Amsterdam UMC, location AMC between September 2016 and March 2020. The patients were selected for the study by an oral facial maxillary surgeon. The inclusion criteria were age ≥ 18 years; ASA class 1 and 2; no congenital anomalies, including cleft lip and/or palate; and sufficient command of the Dutch language. Exclusion criteria were obstructive sleep apnea syndrome as the reason for treatment, craniofacial syndromes, and previous history of orthognathic surgery. All participants were informed about the aims and protocol of the study and provided informed consent.