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Chapter 6108Materials and methodsParticipantsEligible patients were referred by their dentist to the Department of Oral and Maxillofacial Surgery of the Amstelland hospital in Amstelveen, The Netherlands, for removal of an impacted mandibular third molar. Patients with asymptomatic impacted mandibular third molars that underwent a coronectomy between January 2019 and December 2019 were included. Inclusion criteria were age 18 years or older, healthy (American Society of Anesthesiologists (ASA) 1), willing to participate, and able to read, understand, and answer the questionnaire. Exclusion criteria were: known allergies to ibuprofen or chlorhexidine; smoker; periodontitis; a medical history involving renal failure, blood diseases, or chronic liver disease; taking anti-aggregants or corticosteroids, currently, or in the 15 days prior to surgery; breastfeeding or pregnant; local infection, preoperatively or in the 15 days prior to surgery; previous radiation therapy to the maxillofacial region; uncontrolled diabetes; taking antibiotic prophylaxis for endocarditis; or any local pathology. This prospective study was reviewed and approved by the institutional Medical Ethics Committee of the Amsterdam University Medical Center. The study was conducted in accordance with Good Clinical Practice and the Declaration of Helsinki, as amended in Somerset West, Republic of South Africa, in 1996. Patients were provided with information to explain the study, and all patients consented to participate in the study. Patients also agreed to attend two appointments (the surgery and a control visit). All patients were fully informed about the surgical procedure, postoperative care, possible complications, and follow-up examinations. Each patient was informed that they had the opportunity to withdraw from the study at any time, without consequences regarding the treatment. Study procedureThis study included 50 patients. Preoperatively, patient demographic and medical information was recorded, and the patients were labeled patient 1 to patient 50, to ensure confidentiality of patient information during the study. We recorded the location of the impacted third molar, and we performed an X-ray orthopantomogram to assess the degree of impaction (Pell and