Page 30 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt

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RV/LV-ratio is lacking. A frequently applied method for determining a cut-off value is calculation of the Youden Index, which is the cut-off value belonging to the highest sum of the combination of sensitivity and specificity, derived from the ROC-analysis. Since this cut-off value is not necessarily the optimal cut-off value within the clinical context, we chose a range of cut-off values to determine an optimal cut-off value.
Statistical analyses were performed using SPSS (version 20.0, SPSS, inc, Chicago, Illinois) and R (R Foundation for Statistical Computing, Vienna, Austria, 2013) . P-values <0.05 were considered statistically significant.
Results
Baseline characteristics of both groups are summarized in table 2. Between groups there were expected differences in mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), right atrial pressure (RAP) and cardiac output (CO). The average interval time between the baseline right heart catheterization and CTPA in the precapillary PH group was 16 ± 7 days and 15 ± 5 days in the control group. Mean values of all three CTPA parameters were significantly different between precapillary PH patients and controls (table 3).
PH (n=51)
71% female 56 ± 16
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CTEPH
mPAP (mmHg)
PAWP (mmHg)
PVR (Dyne.s/cm5)
RAP (mmHg)
CO (L/min)
Table 2: Baseline characteristics. IPAH = idiopathic pulmonary arterial hypertension; CTEPH = chronic trombo-embolic pulmonary
hypertension; mPAP = mean pulmonary artery pressure; PAWP = pulmonary artery wedge pressure; PVR = pulmonary vascular resistance; RAP = right atrial pressure; CO = cardiac output. *p<0.05 compared with the PH group.
Gender
Age (years) Precapillary PH
IPAH
Controls (n=25)
76% female 55 ± 15
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48 ± 16 7 ± 3 774 ± 452 8 ± 5 5.1 ± 0.3
16 ± 4* 6 ± 3 126 ± 70* 3 ± 2* 6.9 ± 0.4*