Page 175 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt

Figure 1: Rest-to-exercise responses at 40% of Wmax. Data is presented as mean and standard error. Blue bars represents the data at rest, red bars represents the data during exercise at 40% of Wmax. A: CI = cardiac index. CI significantly increased in both groups during exercise, with a larger increase in CI in the control subjects (p-interaction: 0.003). B: SVI = stroke volume index. SVI did not increase in both groups. C: HR = heart rate. * = p-interaction adjusted for age. HR significantly increased during exercise in both groups during exercise, with a larger increase in HR in the control subjects (p-interaction: 0.039). After correction for age, the rest-to-exercise response in HR between groups was not different (p=0.300*). D: mPAP = mean pulmonary artery pressure. mPAP significantly increased in both groups during exercise, with a larger increase in mPAP in PH patients (p-interaction: 0.005). E: RVPsys = right ventricular systolic pressure. RVPsys significantly increased in both groups during exercise, with a larger increase in RVPsys in PH patients (p-interaction: 0.019). F: Pmax = maximal isovolumic pressure. Pmax significantly increased in both groups during exercise. G: TPVR = total pulmonary vascular resistance. TPVR significantly decreased in PH patients during exercise. H: VO2 = oxygen consumption. VO2 significantly increased in both groups during exercise, with a larger increase in VO2 in control subjects (p-interaction: 0.006). I: SvO2 = mixed venous oxygen saturation. SvO2 significantly decreased in both groups during exercise.
The exertional contractile reserve (ΔEes)
From rest-to-exercise, RV contractility (Ees) increased significantly in control subjects, but not in PH patients (p-interaction=<0.001), implying an impaired exertional contractile reserve (figure 2).
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