Page 156 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt

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were applied to assess the relation between native T1-values and hemodynamic and cardiac parameters of disease severity: right atrial pressure (RAP), mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), cardiac index (CI), RV stroke volume index (SVI), RV end- diastolic volume index (RVEDVI), RV end-systolic volume index (RVESVI), RV ejection fraction (RVEF) and NT Pro-BNP. All analyses were performed using SPSS for Windows version 20.0 and Graphpad Prism for Windows version 5.0. P-values <0.05 were considered statistically significant.
Results
Patient characteristics, hemodynamics and standard CMRI measurements are summarized in table 1.
Female (%)
Age (years) Heart rate (bpm) Hemodynamics:
mPAP (mmHg) PAWP (mmHg) PVR (dyn*s/cm5) RAP (mmHg)
CI (L/min/m2) CMRI:
RVEDVI (ml/m2) RVESVI (ml/m2) RVSVI (ml/m2) RVEF (%)
N=70 (IPAH n=46; PAH-SSc n=14; CTEPH n=10)
73 54 ± 16 79 ± 14
47 ± 13 8 ± 3 634 ± 342 7 ± 4
3 ± 1
Control subjects (n=10)
40 20 ± 1 74 ± 11
- - - - -
- - - - - -
P-value
0.04 <0.001 0.280
82 ± 38 51 ± 37 30 ± 12 42 ± 16 65 ± 11 1393 ± 2283
LVEF (%)
NT ProBNP (ng/L)
Table 1: Patient characteristics. mPAP = mean pulmonary artery pressure; PAWP = pulmonary arterial wedge pressure; PVR = pulmonary vascular resistance, RAP = right atrial pressure; CI = cardiac index; CMRI = cardiac magnetic resonance imaging;
RVEDVI = indexed right ventricular end-diastolic volume; RVESVI = indexed right ventricular end-systolic volume; RVSVI = right ventricular stroke volume index; RVEF = right ventricular ejection fraction; LVEF = left ventricular ejection fraction.