Page 71 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek

Figure 4.4. Immune cell populations within the CD4+ T cell major immune cell lineages that are significantly different between NT1 patients with recent disease onset and HLA-matched healthy controls. Frequencies are depicted as a percentage of CD45+ cells. Antibody profiles of the clusters in the figure itself are described in comparison with the immune cell cluster on the far left to highlight the differences between the clusters. The complete antibody profile of the depicted clusters is as follows (from left to right):
Cluster 10: CD45RO+CD3+CD4+CD5+CD7+CD27+CD28+CD127+CD161+CCR6dim
Cluster 9: CD45RO+CD3+CD4+CD5+CD7-CD27+CD28+CD127+CD161+CCR6dim
Cluster 13: CD45RO+CD3+CD4+CD5+CD7dimCD25+CD27+CD28+CD161dimCCR6dim
Cluster 17: CD45RO+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CCR7dimPD1dim
Cluster 25: CD45RO+CD3+CD4+CD5+CD7+CD27+CD28dimCD56dimCD127+CD161+CCR6dim KLRG1+
Cluster 30: CD45RA+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CD161+CCR7dim
Cluster 32: CD45RO+CD3+CD4+CD5+CD7dimCD25dimCD28+
Cluster 33: CD45RO+CD3+CD4+CD5+CD28+CD161+CCR6dim
Cluster 36: CD45RO+CD3+CD4+CD5+CD7dimCD8a/bdimCD27+CD28+CD69dimCD127+CCR7dim IgM+.
Information on significantly different clusters within other major immune cell lineages including their antibody profile can be found in Supplementary table 4.2. Statistical testing was performed using two- tailed Mann-Whitney U tests for unpaired samples with correction for multiple testing (Benjamini- Hochberg procedure).
* = p <0.05; ** = p <0.01. HLA = human leucocyte antigen; NT1 = narcolepsy type 1.
Immune cell composition in peripheral blood
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