Page 72 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek

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Chapter 4
Figure 4.5. Replication of significantly different immune cell populations reported in earlier publications. A. Regulatory CD4+ T cells (CD4+CD25+CD127-) were found more frequently in NT1 patients with recent disease onset compared to HLA-matched controls. B. Central and effector memory CD4+ T cell frequencies were similar in both participant groups. C. CD27-CD8+ T cells were less frequent in NT1 patients with recent disease onset compared to HLA-matched controls. D. The frequency of CD3- CD56+ natural killer cells was comparable between both participant groups. Statistical testing was performed using two-tailed Mann-Whitney U tests for unpaired samples.
HLA = human leucocyte antigen; NT1 = narcolepsy type 1.
NT1 with disease onset < 2 years vs > 2 years
Differences between NT1 patients within 2 years after disease onset compared with those with onset longer than 2 years before blood was drawn were less pronounced than those between patients with recent onset and controls. However, several immune cell populations within the B cell major immune cell lineage were significantly more frequently found in NT1 patients with recent disease onset. All clusters that were found to be different between these two groups of people with narcolepsy can be found in Supplementary table 4.3.