Page 69 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek

Immune cell composition in peripheral blood
Figure 4.1. Peripheral blood mononuclear cell populations derive from multiple major immune cell lineages. HSNE embedding showing landmarks that represent all live, CD45+ immune cells isolated from participant PBMCs (18.8 x 106). Colours in the upper plot delineate the different major immune cell lineages (CD8+ T cells, naïve and memory CD4+ T cells, B cells, CD3-CD7+ cells, myeloid cells and TCRγδ cells). These colours correspond with the colours above the columns in the lower part of the figure. In this plot, rows represent the 39 antibodies identified on immune cells in the different populations. Blue indicates low values of this antibody on the surface on the immune cells in this specific population, while red indicates high values of this antibody on the cell surface. The antibodies that are used to characterize the different immune cell populations derived from HSNE analysis are highlighted in bold.
67
4