Page 94 - Human Bile Acid Metabolism: a Postprandial Perspective

Chapter 5
Table 1. Effects of short-term fasting and single-dose gDCA administration on plasma bile acid composition in healthy men
Bilogram, μmol/L
14 h FAST
0.70 [0.63] 987.1 [859.1]
0.04 [0.04] 10.13 [3.78]
0.05 [0.04] 170.3 [130.2]
0.02 [0.01] 14.7 [17.6]
0.04 [0.04] 21.2 [46.0]
0.14 [0.26] 353.5 [399.6]
0.01 [0.02] 40.9 [40.0]
0.11 [0.21] 66.8 [160.5]
0.03 [0.12] 121.1 [227.1]
0.0 [0.01] 17.1 [45.3]
40 h FAST P
0.54 [0.60] 0.86 987.5 [515.2] 0.31
0.20
0.02 [0.02] 0.14 7.4 [2.69] 0.14
0.11
0.04 [0.07] 0.91 159.3 [158.6] 0.31
0.55
0.01 [0.02] 0.77 16.4 [27.4] 0.77
0.87
0.01 [0.03] 0.18 16.7 [10.8] 0.31
0.46
0.06 [0.11] 0.86 452.9 [279.6] 0.44
0.28
0.02 [0.02] 0.44 35.4 [58.8] 0.86
0.28
0.09 [0.42] 0.83 108.7 [144.2] 0.26
0.30
0.28 [0.74] 0.51 108.1 [171.1] 0.44
0.28
0.01 [0.03] 0.91 17.4 [34.4] 0.77
0.21
—gDCA 1.10 [2.14] 1126.7 [621.0]
0.10 [0.20] 22.1 [106.6]
0.13 [0.25] 155.4 [143.2]
0.0 [0.07] 21.8 [22.5]
0.10 [0.34] 26.8 [58.6]
0.35 [0.28] 414.1 [285.3]
0.02 [0.05] 48.7 [31.8]
0.22 [0.39] 69.0 [61.9]
0.10 [0.14] 152.0 [141.4]
0.01 [0.08] 33.4 [47.4]
+gDCA P 0.73 [1.13] 0.11 1104.3 [686.7] 0.88
0.63
0.11 [0.75] 0.25 27.8 [27.5] 0.28
0.16
0.05 [0.09] 0.37 92.7 [112.1] 0.72
0.69
0.0 [0.01] 0.16 15.3 [20.8] 0.33
0.63
0.09 [0.29] 0.21 23.6 [30.0] 0.06
0.62
0.22 [0.15] 0.37 454.3 [169.1] 0.72
0.34
0.0 [0.02] 0.08 54.6 [35.3] 0.39
0.50
0.23 [0.34] 0.31 48.8 [101.3] 0.58
0.84
0.07 [0.04] 0.24 231.1 [133.0] 0.02*
0.17
0.0 [0.0] 0.04* 21.0 [18.2] 0.06
0.78
Experiment 1, n = 9 men
Experiment 2, n = 10 men
Total bile acids
Unconj. CA
G-conj. CA
T-conj. CA
Unconj. CDCA
G-conj. CDCA
T-conj. CDCA
Unconj. DCA
G-conj. DCA
T-conj. DCA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
baseline AUC
2-way RM- ANOVA
Data are median and [interquartile range]. AUC, area under the curve; TBA, total bile acids; G-conj., glycine conjugated; T-conj., taurine conjugated; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; RM, repeated measures. *P < 0.05.
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