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Chapter 8260Medical filesPsychodiagnostic filesFiles used by professional caregiversFigure 3. Proportion of genetic diagnoses, variants of uncertain significance, and other (N=87) reported (blue) and missing (orange) in medical files, psychodiagnostic files, or files used by professional caregivers. * indicates p ≤ .01; *** indicates p ≤ .001. Factors associated with availability of information on genetic etiologySignificant associations were found between presence of information on genetic etiology and age (r=-0.16, p=.002), the severity of ID (X2 (3, N = 378) = 28.898, p < .001), and the type of relationship with the legal representative (X2 (2, N = 380) = 17.323, p < .001) (Supplementary Table A). Post hoc analysis revealed that individuals with moderate and severe ID were more likely to have information in their files reporting on genetic etiology compared to individuals with mild ID (p < .001). Individuals with a family member as a legal representative were more likely to have this information reported compared to those without a legal representative or those with a non-family member as legal representative (p < .001). No significant associations were found between information on genetic etiology and sex, location of receiving care, presence of medical care on site, and 24 hours support.The logistic regression model predicting the effects of age, level of ID, and legal representative on the likelihood that individuals have information on genetic etiology reported in any file, was statistically significant (X2(5) = 48.367, p < .001), explaining 18.2% (Nagelkerke R2) of the variance in presence of information on genetic etiology and correctly classified 69.1% of cases (Table 2). Increasing age was associated with a decreased likelihood of reporting information on genetic etiology (odds ratio [OR] = 0.971, p < .001). Individuals with a moderate, severe or profound ID were respectively 3.36, 6.32, and 4.02 times more likely to have reported information on genetic etiology compared to individuals with a mild ID. Individuals with a Annelieke Muller sHL.indd 260 14-11-2023 09:07