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Biomaterials in TMJ replacement633soundness of each article, a quality evaluation was performed using the 2011 Oxford Centre for Evidence-Based Medicine LOE65 (Level of Evidence) recommendations. The quality was categorized from levels I to IV; level V studies were not included. The initial search returned 10,433 published articles. Subsequently the number of hits was reduced by removing all duplicates and reviewing the titles of these articles. This led to a total of 113 articles, which were evaluated by reading through the abstract. Articles not containing a reference to the temporomandibular joint in the abstract were excluded, leading to a further exclusion of 37 articles. By reading through the final 76 full-text articles, applying the inclusion criteria, a total of 37 articles were included in the systematic search. Reasons for exclusion were: Article written in other language than English, Dutch or French; Full text not accessible. Additionally 16 articles were included through hand searching reference lists of the included articles. Finally, in order to provide a sound biomaterial background, an additional 8 articles were handpicked by a biomaterial engineer from the specialized literature, to provide further unbiased details on material specifics and properties, while still maintaining the methodological soundness and objectivity of the systematic search results. The performed search has been summarized in the PRISMA-flow chart (Fig. 1). History of materials used in temporomandibular joint reconstructionThe importance of appropriate selection of prosthetic materials has clearly marked the history of TMJ prosthesis design, as many designs have been conceived, yet only a few remain. The use of inadequate materials can, for instance, result in metal hypersensitivity, foreign body giant cell reaction, heterotopic ossification, and even implant loosening and failure. Below, a short summary of the history of the different types of prostheses, with their respective materials has been provided.(15–20) Nikolas de Meurechy NW.indd 63 05-06-2024 10:14