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Animal experiment: Histological analysis of the LPM reattachment2318connective tissue, keeping the enthesis well in place during the duration of our experiment. Furthermore, clinical evaluation showed that the sheep’s pre-operative weight was regained and kinematic analysis proved that restoration of proper laterotrusive function was achieved, despite the absence of full osseointegration of the enthesis into the scaffold.(16) Thus while it would have been preferable to achieve proper osseointegration, being more predictable and stable compared to the soft tissue connection formed between the LPM and the TMJR, a functional reattachment was achieved nevertheless. ConclusionAn in vivo sheep experiment was conducted to investigate a novel patientspecific TMRJ. Both a subcondylar scaffold and tunnel were designed for the reinsertion of the LPM (enthesis). Histological analysis of the enthesis reconstruction in preselected samples revealed an uninterrupted, functional, fibrotic reinsertion of the LPM onto the TMJR, restoring the muscle’s function. Multiple osteogenic islands within the enthesis scaffold. Further research should include application of bone marrow aspirate and growth factors, intra-operative monitoring the approximation of the bony part of the enthesis to the scaffolded area and minimizing mobilization during healing, to attempt osseous integration. Such experiment may only be possible in human subjectsNikolas de Meurechy NW.indd 231 05-06-2024 10:14