Page 78 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Chapter 3
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Table 2. Imaging and breathing FRC, mL/kg a
0 cmH2O (n=12)
6.8 (1.0-11.2) 0/10 (0%) 2.9 (0.9-9.4) 1.5 (0.9-8.8) 5/11 (46%) 19 (2-37)
5 cmH2O (n=11)
10.1 (1.1-16.8) 2/10 (20%) 7.1 (1.0-14.1) 7.0 (0.9-14.1) 5/11 (46%)
36 (4-49)
8 cmH2O (n=12)
13.7 (5.6-16.1) 4/11 (36%) 10.1 (5.4-17.0) 9.5 (5.2-16.4) 4/11 (36%)
31 (13-42)
12 cmH2O (n=10)
14.2 (9.4-21.6) 6/10 (60%) 17.4 (7.4-24.4) 12.6 (7.3-24.4) 2/10 (20%)
15 cmH2O (n=31)
18.8 (10.9-22.4) 22/30 (73%) 19.7 (14.2-23.1) 18.9 (8.2-22.3) 5/31 (16%)
36 (27-45)
P-value
FRC >15 mL/kg on CPAP, n (%) c Maximum FRC on CPAP, mL/kg b Final FRC on CPAP, mL/kg b Apnea, n (%) c
0.003 <0.001 <0.001 0.003 0.185 0.096
Breathing rate over time, (breaths/min) a
Breathing rate, AUC b
Maximum breathing rate on CPAP, breaths/min a
34 (26-43)
Bulging, n (%) d
Significant bulging, n (%) d Pneumothorax, n (%) d CPAP belly, n (%) d
0/11 (0%) 0/11 (0%) 1/11 (9%) 0/11 (0%)
3/11 (27%) 1/11 (9%) 0/11 (0%) 1/11 (9%)
1/11 (9%) 1/11 (9%) 1/11 (9%) 0/11 (0%)
0/10 (0%) 0/10 (0%) 0/11 (0%) 1/10 (10%)
7/31 (23%) 1/31 (3%) 0/31 (0%) 3/31 (10%)
0.159 0.274 0.347 0.756
171 (66-360) 27 (25-40)
301 (144-468) 56 (43-62)
309 (170-433) 42 (31-67)
326 (274-400) 53 (38-62)
351 (287-413) 48 (38-59)
0.118 0.028
Numerical data presented as median (Q1-Q3) compared using a a) linear regression mixed model, or b) Kruskal-Wallis test. Categorical data presented as n, (%) compared using a c) Log-Rank survival test, d) Fisher’s exact test. FRC; Functional Residual Capacity.