Page 77 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Higher CPAP levels improve functional residual capacity at birth in preterm rabbits
Breathing rates were not statistically significant different across all groups over time (p=0.096, Figure 4a and Table 2) or when calculated as area under the curve (AUC) (p=0.118, Figure 4b and Table 2). Maximum breathing rates of kittens receiving 0 cmH2O CPAP were significantly lower than those on 5, 12 and 15 cmH2O of CPAP (p=0.028, Figure 4c and Table 2). Similarly, while the incidence of apnoea was not significantly different between groups (p=0.185, Figure 4d and Table 2), the risk of apnoea over the first 10 min after birth was approximately double in the 0 and 5 cmH2O groups compared to the 12 and 15 cmH2O CPAP groups.
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Figure 4. Spontaneous breathing. Effect of CPAP level on spontaneous breathing. a) Median (Q1-Q3) breathing rate for each group plotted over time (t = 0, equipment ready). b) Area under the curve (AUC) of the breathing rate measured over the first 10 min. c) Maximum breathing rate achieved while breathing spontaneously on CPAP for each of the different CPAP levels. d) Time line for the risk (%) of kittens becoming apnoeic (t0 = equipment ready) within each CPAP group. An asterisk (*) indicates significant differences between groups.
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