Page 76 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Chapter 3
Comparison of initial CPAP levels
During the first 10 min after birth, FRC was significantly lower (p=0.003) in kittens receiving CPAP of 0 and 5 cmH2O compared to kittens receiving a CPAP of 12 and 15 cmH2O (Figure 3a and Table 2). Significantly fewer kittens reached FRCs >15 mL/kg on a CPAP of 0 cmH2O, compared to CPAP levels of 8, 12 and 15 cmH2O (p <0.001, Figure 3b and Table 2). Kittens supported by 0 and 5 cmH2O of CPAP achieved significantly lower maximum FRCs compared to kittens receiving CPAP levels of 12 or 15 cmH2O (p <0.001, Figure 3c and Table 2). The final FRC measurement was significantly lower in kittens receiving 0 cmH2O of CPAP compared to 15 cmH2O CPAP (p=0.003, Figure 3d and Table 2).
Figure 3. Functional residual capacity (FRC). Effect of CPAP level on FRC. a) Median (Q1-Q3) change in FRC over time (t0 = equipment ready) within each group; data obtained during IPPV has been included. b) Percentage of kittens in each group reaching FRC > 15 mL/kg while on CPAP. c) Median (Q1-Q3) of maximum FRC that kittens reached while on CPAP. d) Median (Q1-Q3) of final FRC measurement while on CPAP, measured either at end-experiment or prior to the start of ventilation. An asterisk (*) indicates significant differences between groups.
72