Page 109 - 89Zr-Immuno-PET:Towards a Clinical Tool to Guide Antibody-based Therapy in Cancer
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Noise-induced variability of 89Zr-immuno-PET
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Figure 3. Repeatability coefficients (%) and their 95% CIs of normal tissue uptake of Zr-89-mAbs. a) the combined group of manually delineated organs for 89Zr-antiCD20, b) blood pool for 89Zr-antiCD20, c) the combined group of manually delineated organs for 89Zr-antiCD20 (18 MBq74inj), 89Zr-antiEGFR (18 MBq37inj) and 89Zr-antiCD44 (18 MBq37inj), d) blood pool for 89Zr-antiCD20 (18 MBq74inj), 89Zr-antiEGFR (18 MBq37inj) and 89Zr-antiCD44 (18 MBq37inj).
antiCD44 mAb at D4 (18 MBq37inj) and for 89Zr-antiEGFR mAb at D6 (18 MBq37inj). For 89Zr-anti-CD44 mAb the RC for SUVpeak increased from 21 to 28% RC (D1 to D4). These values were lower than for 89Zr-anti-CD20 mAb (Table 1). However, data for 89Zr-antiCD44 mAb were acquired at different time points after injection (D1 and D4) compared to 89Zr-antiCD20 mAb and 89Zr-antiEGFR mAb (D3 and D6). No differences were observed in RC for SUVpeak between all three mAbs at D3-D4, and between 89Zr-antiCD20 mAb and 89Zr-antiEGFR mAb at D6. The differences between SUVmean and SUVmax were significant for the three Zr-89-mAbs combined (D3-D4), as well as on D6 for 89Zr-antiCD20 and 89Zr-antiEGFR combined.
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