Page 85 - Effects of radiotherapy and hyperbaric oxygen therapy on oral microcirculation Renee Helmers

Table 2 presents a summary of the analyzed microvascular parameters. Baseline mean TVD and PVD for all groups was 26±3 mm/mm2. At T5 TVD and PVD in all groups showed a decrease of >10% compared to baseline, a significant difference was only observed for groups I, II and IV (p<0.05) and return to baseline TVD and PVD was first observed at T8 in group III. Additionally, in group IV marked changes in the microcirculation presenting as multiple bud-like telangiectasia was observed at all time points with the most intense presentation at T2 in both animals [Fig. 2]. PPV and MFI remained unaltered across all time points.
Onset of late irradiation effects
Day 42 (T6) Day 49 (T7)
Day 63 (T9)
± 1
± 0** ± 3
± 2
±13 ± 5 ± 6 ± 11
± 1
± 0** ± 3
± 2
± 13 ± 5 ± 6 ± 11
Day 70 (T10) Day 77 (T11)
25 ± 2 25 ± 1 24 ±326±1
Day 56 (T8)
± 3 25 ±023 ± 0 26 ± 4* 25
±890 ± 3 92 ± 6 97 ±19105
± 3 25 ±023 ± 0 26 ± 4* 25
±890 ± 3 92 ± 6 97 ±19 105
±0 100 ±0 100 ±0 100 ±0 100
4
20 ± 2** 21 ± 0**
20± 26 ± 22 ±
74± 81 ± 95 ± 90±
20 ± 20± 26 ± 22 ±
74± 81 ± 95 ± 90±
100 ± 100 ± 100 ± 100 ±
2** 24 2 25 0** 24
19** 78 3 97 2 93 397
30 ± 5* 28 26 ± 4 23
91 ±2591
26 ±2 24 ± 0 27 ± 1 23
± 15** 94 ± 2 97 ± 2 101 ±8 94
± 2 ± 1*
±21 ± 10 ± 4 ±6
± 1 ±1 ± 2 ± 1*
91 ± 25 91
94 ± 15 105
110 ± 13 101 ± 4 106 ± 21 96 ±6
2** 21 ± 0** 26
25 26 28
2** 24 2 25 0** 24
19** 78 3 97 2 93 3 97
±2 24 ± 0 27 ± 1 23
± 15** 94 ± 2 97 ± 2 101 ±8 94
± 21 ± 10
0 100±0 100 0 100±0 100 0 100±0 100 0 100±0 100
±0100 ±0100 ±0 ±0100 ±0100 ±0 ±0100 ±0100 ±0 ±0100 ±0100 ±0
333333 333333 333333 333333
94 ± 15 110 ± 13 106 ±21
25 ± 2
24 ±3
30 ± 5*
26 ± 4 23
105 101 96
83