Page 42 - Effects of radiotherapy and hyperbaric oxygen therapy on oral microcirculation Renee Helmers

Chapter 2
Table 4. Summary of microcirculation data (vessels with diameters (Ø) <25 μm). All parameters are presented in mean±SD. For blood vessel diameter change (∆Øbv), the negative in front of the number indicates vasodilation, all other positive ∆Øbv data coincide with vasoconstriction.
To correct for anatomical variations between animals, datasets (TVD, PVD, and Øbv) were also normalized with respect to baseline and are expressed as percentages [%].
NB
T0: BL T1 (FiO2: 21%) (FiO2: 55%)
T2 T3 (FiO2: 100%) (FiO2: 21%)
TVD [mm/mm2] 38 ± 12 33 ± 10** 31 ± 8** 37 ± 12 TVD [%] 100 ± 0 87 ± 9** 82 ± 12** 95 ± 7 PVD [mm/mm2] 38 ± 11 33 ± 9** 30 ± 7** 36 ± 11
PVD [%] PPV [%]
Øbv [μm]
Øbv [%] ∆Øbv [μm] MFI [AU]
100 ± 0 88 ± 9** 80 ± 11** 94 ± 7 97 ± 5 96 ± 4 94 ± 4 96 ± 4 4.1 ± 0.3 3.8 ± 0.5* 3.7 ± 0.6* 4.1 ± 0.7 100 ± 0 91 ± 5* 90 ± 9* 98 ± 12
0 ± 0 0.35 ± 0.17* 0.40 ± 0.33* 0.05 ± 0.48 3 ± 0 3 ± 0 3 ± 0 3 ± 0
Øbv blood vessel diameter, AU arbitrary unit, BL baseline, FiO2 fraction of inspired oxygen, HB hyperbaric, NB normobaric, MFI microvascular flow index, μm micrometer, PPV proportion of perfused vessels, PVD perfused vessels density, TVD total vessel density
**p<0.01 vs. T0, RM ANOVA
Figure 5. Multiparameter graph illustrating trends between blood vessel diameters (Øbv), normalized perfused vessel density (PVD), mean arterial pressure (MAP), and partial pressure of oxygen in arterial blood (paO2).
NB normobaric, HB hyperbaric
DISCUSSION
The main research objectives were to generate a model in which HBOm of the sublingual microcirculation in response to hyperoxia under NB and HB conditions could be performed and to measure and describe these changes in
*p<0.05 vs. T0, RM ANOVA
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