Page 121 - Effects of radiotherapy and hyperbaric oxygen therapy on oral microcirculation Renee Helmers

ANOVA or Friedman test was used to detect overall time effects. Significant main effects were subsequently analyzed using paired samples t-test with Bonferroni correction. A linear regression analysis was performed to detect whether (previous) smoking, chemotherapy or dentition state (dentate vs. edentulous) had a significant association on the outcome of microcirculation parameters. McNemar test was used to check whether proportion of healthy tissue (class I type angioarchitecture) was significant different over time. Descriptive and statistical analyses were performed using the SPSS Statistics software package (IBM SPSS Statistics version 27, IBM Corp. Armonk, NY, USA). All data are presented as mean ± standard deviation (SD). A p-value of <0.05 was considered statistically significant.
Figure 1. Patient selection flowchart.
RESULTS
The noninvasive oral microcirculation measurements were well tolerated by all patients and no pain or discomfort was experienced or reported. Radiation dose, indications for HBOT (prophylactic or therapeutic) and patient demographics are presented in Table 1. Microcirculation image quality recorded from the buccal and gingival tissue with the CC was excellent with sharp high-resolution and sufficient contrast (CC brightness=450 in all measurements) to observe the
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Effects of HBOT on late irradiation injury
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