Page 39 - Bladder Dysfunction in the Context of the Bladder-Brain Connection - Ilse Groenendijk.pdf

A systematic review and meta-analysis of the central innervation of the lower urinary tract 37 Table 4: ALE results of PFMC and micturition tasks. Numbers of clusters correspond with numbers in figures
2 and 3.
Cluster
x
y
z
ALE
R/L
Label
Pelvic floor muscle contraction
1
6
-26
66
0.024029579
R
Primary motor cortex (BA 4)
1
4
-16
58
0.017922753
R
Supplementary motor area (BA 6)
1
-6
-26
66
0.017806701
L
Primary motor cortex (Ba 4)
1
-2
-14
66
0.016178703
L
Supplementary motor area (BA 6)
1
0
-8
66
0.015730955
L
Supplementary motor area (BA 6)
1
-8
-10
74
0.014048412
L
Supplementary motor are (BA 6)
2
2
4
50
0.020907918
Mid cingulate gyrus (BA6)
3
-12
-16
6
0.017822513
L
Thalamus (BA 50)
4
60
-34
22
0.018866712
R
Insula (BA 13)
5
-14
-50
-14
0.012372754
L
Cerebellum, Anterior Lobe
6
60
12
0
0.012290734
R
Inferior frontal gyrus, pars opercularis (BA 44)
7
-8
-20
-16
0.011285471
L
Brainstem, Substania Nigra
8
6
-20
-16
0.011667801
R
Brainstem, Red Nucleus
9
12
-20
0
0.009602174
R
Thalamus (BA 50)
10
52
12
-8
0.009869569
R
Posterior superior temproral gyrus (BA22)
Micturition
1a
-6
-24
2
0.014630636
L
Thalamus (BA 50)
1b
8
-32
-22
0.013637082
Pontine micturition center
1c
-2
-30
-8
0.012890372
Periaquatuctal grey
1d
-6
-14
-4
0.010864062
L
Thalamus (BA 50)
2
-2
4
44
0.011646116
Cingulate Gyrus (BA 6)
3
-30
32
36
0.009706984
L
Middle Frontal Gyrus (BA 9)
3
-30
42
38
0.009270421
L
Middle Frontal Gyrus (BA 9)
4
38
34
6
0.013441784
R
Insula (BA 13)
5
4
24
48
0.01143695
Superior Frontal Gyrus (BA 8)
6
0
-14
-24
0.009587356
Ventral pons
7
-58
6
4
0.0091044
L
Inferior frontal gyrus, pars opercularis (BA 44)
DISCUSSION
This systematic review and meta-analysis provide a unique overview on the supraspinal areas involved in LUT motor control (pelvic floor muscle contraction and micturition), showing raw data of the acquired PET and fMRI evidence of the past three decades. Fur- thermore, ALE-analysis enabled us to extract from all raw data across studies the most commonly and reproducibly activated supraspinal areas involved in LUT motor control.
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