Page 125 - Bladder Dysfunction in the Context of the Bladder-Brain Connection - Ilse Groenendijk.pdf

The validation of the Dutch OAB-q SF questionnaire 123 Table 2. The reproducibility is presented in term of the intraclass correlation coefficient (ICC) and the limits
of agreement (LOA)
aCalculated as : y= mean(change) ± 1.96 X standard deviation (change).
Criterion validity
Using Pearson’s correlation coefficient a moderate to very strong correlation was detected between the OAB-q SF symptom bother and the UDI-6 and the ICIQ-Q. The criterion validity of the OAB-q SF HRQOL was evaluated by calculating the correlation with the IQIQ-BS and the EQ-5D-5L index values and VAS. Calculating the correlation with the EQ-5D-5L index values, the spearman correlation coefficient was used since no linear relationship was found between the OAB-q SF HRQOL and the EQ-5D-5L index value. Cor- relations demonstrated a weak to strong correlation (See Table 3 for Rho and P-values).
Table 3. Criterion validity measured using the Pearson’s Correlation coefficient.
6
Change (mean ± SD)
ICC (95%CI)
LOAa
OAB-q SF symptom bother
-4.23 ± 13.89
0.79 (0.66 – 0.88)
-31.45 – 22.99
OAB-q SF HRQOL
2.37 ± 10.83
0.85 (0.76 – 0.91)
-18.84 – 23.58
UDI-6
ICIQ-Q
ICIQ-BS
EQ-5D-5L index value
EQ-5D-5L VAS
Test
OAB-q SF Symptom bother
0.56 (<0.001)
0.84 (<0.001)
OAB-q SF HRQOL
-0.67 (<0.001)
0.46 (<0.001)a
0.49 (0.001)
Retest
OAB-q SF Symptom bother
0.72 (<0.001)
0.83 (<0.001)
OAB-q SF HRQOL
-0.70 (<0.001)
0.43 (0.002)a
0.33 (0.016)
Values are Rho (P-value)
aSpearman’s correlation coefficient because of nonparametric correlation.
Construct validity
All predefined hypotheses were confirmed:
1. The reference group did have lower OAB-q SF symptom bother scores and higher
OAB-q SF HRQOL scores compared to the patient group (Table 1).
2. Patients with a higher UDI-6 score had a higher OAB-q SF symptom bother score
(Table 3).
3. Patients with a higher ICIQ-OAB Q (questions) score had a higher OAB-q SF symptom
bother score
4. Patients with a higher ICIQ-OAB BS (bother scale) score had a lower OAB-q SF HRQOL
score (Table 3).
5. Patients with a lower EQ-5D-5L index value and a lower EQ-5D-5L VAS had a lower
score on the OAB-q SF HRQOL (Table 3).