Page 124 - Bladder Dysfunction in the Context of the Bladder-Brain Connection - Ilse Groenendijk.pdf

122
Chapter 6
Table 1. Patient characteristics and baseline outcomes of measurements
Reference group N = 51
Patient group N = 52
P-value
Age, yrs
41 (±15)
64 (±13)
0.02a
Gender
0.24b
Male
14 (28%)
20 (39%)
Female
37 (72%)
32 (61%)
Baseline scores
OAB-q SF Symptom bother
12.4 ± 15.4
63.8 ± 21.6
<0.001a
OAB-q SF HRQOL
95.9 ± 5.4
50.9 ± 19.1
<0.001a
EQ-5D-5L index value
0.881 ± 0.156
0.738 ± 0.212
0.086a
EQ-5D-5L VAS
76.1 ± 14.3
71.7 ± 17.3
0.043a
UDI-6
8.9 ± 9.1
57.7 ± 20.7
<0.001a
ICIQ-OAB Q (questions)
2.3 ± 1.8
10.4 ± 2.9
0.001a
ICIQ-OAB BS (bother scales)
3.8 ± 6.3
29.4 ± 8.1
0.037a
aStudent’s T-test bChi square test
Content validity
Content validity was confirmed during the face-to-face evaluation of the questionnaire. Question 8 of the OAB-q SF HRQOL subscale was discussed, but did not lead to changes in the questionnaire. Furthermore, the face-to-face evaluation demonstrated that pa- tients found the questionnaire understandable, easy to complete and clear.
Internal consistency
The internal consistency of the questionnaire was tested good for both subscales. Cronbach’s Alphas between 0.70 and 0.95 reflect adequate internal consistency. In the patient group the OAB-q SF symptom bother subscale the Cronbach’s Alpha scores were 0.84 and 0.87 for test and retest, respectively. For the OAB-q SF HRQOL subscale the Cronbach’s Alpha were 0.88 and 0.91 for test and retest, respectively.
Reproducibility
In the patient group, the second questionnaire was returned after a mean of 15.8 days (SD ± 11). An adequate reliability was confirmed with ICCs higher than 0.70 for the two subscales of the OAB-q SF. Table 2 lists the ICCs for agreement and LOA ranges for the two subscales of the OAB-q SF.