Page 67 - Quantitative Imaging of Small Tumours with Positron Emission Tomography

Chapter 3 mitigation). As a consequence, IDIF AUCs of uncorrected and PVC images were highly correlated (Supplemental Table 1). Similar results were observed for parent plasma calibrated input curves. Also, kinetic parameter estimates derived from uncorrected images using uncorrected vs. PVC input functions were very similar (Supplemental Table 2); small but significant differences in VT and K1 were observed for LR and LR+HYPRmoving IDIFs, but not when HYPRsingle was applied. Therefore, we continued our analyses using the parent plasma calibrated input functions derived from uncorrected PET images. Figure 3.1: Time-activity curves of relative change in activity concentrations (AC) after PVC using several HYPR settings. Frames of 0-4 minutes (A) and 4-60 minutes (B) post-injection. Results of a typical mediastinal lymph node metastasis are shown. Note the temporality of PVE with a spill in at early timeframes. Corresponding original PET images (C) with the lesion volume-of-interest in red demonstrate blood pool activity near the VOI and increasing tumor-to-background contrast over time. 66