Page 161 - Quantitative Imaging of Small Tumours with Positron Emission Tomography

Chapter 7 Figure 7.5: Summary sensitivity and specificity with 95% confidence region of discrimination between benign and malignant pulmonary nodules with 18F-FDG-PET. Response assessment Impact of PVC on response assessment (Table 4, n=5) was investigated for breast (n=2), rectal (n=1), colorectal (n=1), and NSCLC (n=1). Applied PVC methods were the recovery coefficient-method (n=2), iterative deconvolution (n=2), and both RC-method and iterative deconvolution (n=1). One study did not specify lesion sizes. None of the studies stratified results on PVC for lesion size in secondary analysis. For locally-advanced breast cancer (41), regardless of PVC primary tumour FDG metabolic rate was not able to differentiate between clinical and pathologic responders and non-responders during neoadjuvant chemotherapy (after 2 months). In another study in breast cancer patients PVC did not significantly change prediction of pathologic response with primary tumour SUV during neoadjuvant therapy (after 2 cycles) (42)]. In locally-advanced rectal cancer patients treated with (preoperative) chemoradiotherapy, PVC had no impact on histopathological response prediction, at baseline or after 1 or 2 weeks of therapy 160