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Impact2279via newsletters to adults with 22q11.2DS who participated in studies at Maastricht University Medical Center, which together with ‘s Heeren Loo, offers a specialized clinic for adults with 22q11.2DS. Results of the studies included in this thesis may inform future studies aimed at finding or improving treatment for conditions that are frequently present in adults with 22q11.2DS. For example, a study of the efficacy of treatment for trauma in adults with 22q11.2DS has recently started.In addition to the societal impact of the included studies, mostly health care related, results may also have research implications.The studies described in this thesis that were performed in adults with 22q11.2DS may suggest that 22q11.2DS is associated with precocious aging, which has also been suggested in some other genetic syndromes such as Down syndrome. Because previous research already provided substantial knowledge of genes and affected mechanisms involved in the development of genetic syndromes such as 22q11.2DS, they may serve as a model to study mechanisms and novel treatment options of age-related conditions such as Parkinson’s disease. Recognition of conditions that are common at adult age in genetic syndromes enables future studies that use mouse models or (stem)cells of genetic syndromes. Results of these studies may not only be relevant to adults with a genetic syndrome but may also improve our understanding of the etiology and treatment of these agerelated conditions in the general population.References1. Boot E, Óskarsdóttir S, Loo JCY, et al. Updated clinical practice recommendations for managing adults with 22q11.2 deletion syndrome. Genet Med. Mar 2023;25(3):100344. doi:10.1016/j.gim.2022.11.0122. Óskarsdóttir S, Boot E, Crowley TB, et al. Updated clinical practice recommendations for managing children with 22q11.2 deletion syndrome. Genet Med. Mar 2023;25(3):100338. doi:10.1016/j.gim.2022.11.006