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Chapter 9226and treatment of parkinsonism, Parkinson’s disease in particular, in these genetic syndromes. This study indicated that regular antiparkinsonian medication showed positive effects in most individuals with (suspicion of) Parkinson’s disease, which is of direct clinical relevance. In this study it is recommended that dopaminergic imaging techniques may be considered in patients with a genetic syndrome - who often use anti-psychotic medication - to distinguish neurodegenerative parkinsonism (e.g., Parkinson’s disease) from parkinsonism as side-effect of medication. In addition to a scientific publication, results have been presented at international and national conferences for movement disorders specialists and other neurologists, as well as for physicians for people with intellectual disabilities.The goal of sharing results with different target audiences was to make clinicians aware of the conditions that were frequently present in adults with 22q11.2DS or other genetic syndromes, to improve screening and to emphasize the possibilities for treatment that may ultimately result in better care for adults with a genetic syndrome. In addition, results of the studies included in this thesis demonstrated how a genetic diagnosis may improve clinical care for individuals with an intellectual disability, since some conditions were more frequently seen in adults with 22q11.2DS compared to other genetic syndromes or adults with an intellectual disability in general. For example, knowledge of an increased risk of early-onset Parkinson’s disease in 22q11.2DS compared to the general population and people with an intellectual disability, contributes to recommendations for screening specifically for adults with 22q11.2DS. Therefore, a genetic diagnosis may facilitate a more personalized approach by care providers.Findings of these studies provide information to adults with 22q11.2DS and their relatives about what may be expected at adult age. In addition, it may raise awareness of an increased risk of conditions such as Parkinson’s disease or hearing loss at relatively young-adult age and may help adults with 22q11.2DS or relatives to seek help at an early stage. To make results directly available to adults with 22q11.2DS and their relatives, a presentation was given about post-traumatic stress in 22q11.2DS at the information day of the Dutch 22q11 family organization Stichting Steun 22Q11, and results have been shared via their annual magazine, ‘s Heeren Loo website, and