Page 172 - Characterization of genetic neurodevelopmental disorders at adult age, with a focus on 22q11.2 deletion syndrome - Emma Boersma
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Chapter 5
3. Summary of risk of bias of studies on ocular findings in 22q11.2DS
that underwent a critical appraisal
Study
Risk of bias item
Gokturk et al., 2016
Cirillo et al., 2014
Casteels et al., 2008
Forbes et al., 2007
Vieira et al., 2015
Veerapandiyan et al., 2011
Ryan et al., 1997
Midbari Kufert et al., 2016
1. Target population a close representation of the
national 22q11.2DS population?
2. Was 22q11.2DS genetically proven in all
patients?
3. Some form of random selection used to select
the sample?
4. Likelihood of non-response bias minimal?
5. Data collected directly from the subjects?
6. Acceptable case definition of ocular
manifestations used in the study?
7. Methods of ocular examination described?
8. Same mode of data collection used for all
subjects?
9. Length of the shortest prevalence period for
ocular manifestations appropriate?
10. Were the numerator and denominator for
ocular manifestations appropriate?
Overall risk of bias (out of 10 points) * 3 7 1 4 7 7 7 5
Light blue= yes (low risk), light orange=no/unclear (high risk). *≥7/10 points = very high risk of bias,
excluded from data extraction.
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