Page 172 - Demo

Chapter 51703. Summary of risk of bias of studies on ocular findings in 22q11.2DS that underwent a critical appraisal StudyRisk of bias itemGokturk et al., 2016Cirillo et al., 2014Casteels et al., 2008Forbes et al., 2007Vieira et al., 2015 Veerapandiyan et al., 2011Ryan et al., 1997Midbari Kufert et al., 20161. Target population a close representation of the national 22q11.2DS population?2. Was 22q11.2DS genetically proven in all patients?3. Some form of random selection used to select the sample?4. Likelihood of non-response bias minimal?5. Data collected directly from the subjects?6. Acceptable case definition of ocular manifestations used in the study?7. Methods of ocular examination described?8. Same mode of data collection used for all subjects?9. Length of the shortest prevalence period for ocular manifestations appropriate?10. Were the numerator and denominator for ocular manifestations appropriate?Overall risk of bias (out of 10 points) * 3 7 1 4 7 7 7 5Light blue= yes (low risk), light orange=no/unclear (high risk). *≥7/10 points = very high risk of bias, excluded from data extraction.