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Chapter 5168Supplementary legendSupplementary 1. Search terms for Pubmed, Embase and Cochrane.Supplementary 2. Critical appraisal form.Supplementary 3. Summary of risk of bias of studies on ocular findings in 22q11.2DS that underwent a critical appraisal. Supplementary1. Search terms for PubMed, Embase and Cochrane1.1 PubMed search termsSearch terms used in PubmedDomain (((“22q11 Deletion Syndrome” [MeSH] OR 22q11* [tiab] OR del22q* [tiab] OR DiGeorge [tiab] OR di-george [tiab] OR Velocardiofacial [tiab] OR velo-cardio-facial[tiab] OR VCF-syndrome[tiab] OR (Conotruncal[tiab] AND anomal* [tiab] AND face [tiab]) OR CTAF [tiab] OR “Autosomal dominant Opitz” [tiab] OR “opitz G” [tiab] OR G/BBB [tiab] OR GBBB [tiab] OR “G BBB” [tiab] OR sedlackova [tiab] OR Cayler [tiab] OR catch22 [tiab] OR “catch 22” [tiab] OR shprintzen [tiab] OR “thymic aplasia” [tiab] OR 22q11.2 Deletion Syndrome [tiab]))))Outcome (((((“Eye Diseases”[Mesh] OR “Eye”[Mesh] OR “Ocular Physiological Phenomena”[Mesh] OR refraction [tiab] OR vision [tiab] OR visual [tiab] OR ophthalm* [tiab] OR eye* [tiab] OR conjunctiv* [tiab] OR cornea* [tiab] OR ocular [tiab] OR optic* [tiab] OR orbit* [tiab] OR retina* [tiab] OR sclera* [tiab] OR uvea* [tiab] OR optic-nerve [tiab] OR eyelid* [tiab] OR lacrima* [tiab] OR lens* [tiab] OR pupil* [tiab] OR iris [tiab] OR intra-ocular [tiab] OR intraocular[tiab] OR cataract [tiab] OR blindness [tiab] OR embryotoxon [tiab] OR tortuous-retinal-veins [tiab] OR retinal-vascular-tortuosity [tiab] OR tortuous-retinalvessels [tiab] OR refract* [tiab] OR strabismus [tiab] OR exotropia [tiab] OR esotropia [tiab] OR amblyopia [tiab] OR ptosis [tiab] OR distichiasis [tiab] or astigmati* [tiab]))))Excluding Animals [Mesh:NoExp] OR “mice”[ti] OR “mouse”[ti] OR rat*[ti] OR “nonhuman”[ti] OR veterin*[ti] OR monkey*[ti]1.2 Embase search termsSearch terms Embase Domain exp chromosome deletion 22q11/ or exp DiGeorge syndrome/ or exp velocardiofacial syndrome/ or exp opitz syndrome/ or (22q11*).ti,ab. OR (del22q*OR digeorge OR ‘di george’ OR velocardiofacial OR ‘velo cardio facial’ OR ‘vcf syndrom*’).ti,ab. OR(‘conotruncal’ AND anomal* AND ‘face’).ti,ab,kw. OR (‘ctaf’ OR ‘autosomal dominant opitz’ OR ‘opitz g’ OR ‘gbbb’ OR ‘g bbb’ OR ‘sedlackova’ OR ‘cayler’ OR ‘catch22’ OR ‘catch 22’ OR ‘shprintzen’ OR ‘thymic aplasia’).ti,ab. Outcome (exp eye disease/ OR exp eye/ OR exp ‘visual system parameters’/ OR exp ‘visual system function’/) OR (refraction OR vision OR visual OR ophthalm* OR eye* OR conjunctiv* OR cornea* OR ocular OR optic* OR orbit* OR retina* OR sclera* OR uvea* OR ‘optic nerve’ OR eyelid* OR lacrima* OR lens* OR pupil* OR iris OR ‘intra ocular’ OR intraocular OR cataract OR blindness OR embryotoxon OR ‘tortuous retinal veins’ OR ‘retinal vascular tortuosity’ OR ‘tortuous retinal vessels’ OR refract* OR strabismus OR exotropia OR esotropia OR amblyopia OR ptosis OR distichiasis OR astigmati*).ti,ab.Excluding (animal/ or animal experiment/ or animal model/ or nonhuman/) not human/(mice or mouse or rat? or nonhuman or veterin* or monkey?).ti.Limitations conference abstract or chapter or conference paper or “conference review” or editorial or erratum or letter or note or “review”