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Ocular findings in 22q11.2DS15559 and two other included mainly children.8, 17 All studies included patients with a 22q11.2 deletion confirmed by fluorescence in situ hybridization test and/or multiplex ligation-dependent probe amplification technique.7-9, 17Figure 1. Flow diagram depicting the different phases of the systematic review on ocular findings inpatients with 22q11.2DS (adapted from the PRISMA 2009 flow diagram; http://prisma-statement.org/)a For the complete list of risk of bias of studies, see Supplementary material 3.Quality assessmentSubstantial heterogeneity was present among studies concerning demographics, methods, definitions and outcome measures. The methodology of the studies was poorly described or missing in most studies, complicating comparative evaluation. Ocular findingsVA was (near) normal in most patients (91-94%). In one patient one eye was severely impaired because of a Peters’ anomaly.7 One study described that VA was “lower than normal” in two eyes with high hyperopia and one eye with exotropia and high myopia.9