Page 124 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax

Chapter 7
Table 3. Coronary flow reserve and hyperemic function.
Outcome β
Global LVF
LVEF (%)
End-diastolic volume index (ml/m2)
Baseline -4.86
resistance index and their association with left ventricular
CFR baseline
SE p-value
2.01 0.002 2.10 0.03 2.45 0.02 1.53 0.22 2.19 0.51
3.53 0.17
HMRI baseline
β SE
p-value
Baseline 6.55 4 months 4.66 2 years 5.84 ∆ baseline–4 month -1.89 ∆ baseline–2 years -1.44
-2.12 1.81 0.25 -2.57 1.8 0.16 -4.05 2.16 0.07 -1.48 1.20 0.22 -0.36 1.66 0.83
-0.64 3.01 0.83 4.06 4.23 0.34 2.80 5.26 0.60 -3.05 2.37 0.20 -2.39 3.17 0.45
1.74 2.81 0.54 5.15 3.67 0.17 6.39 4.40 0.15 -0.20 2.13 0.93
4 months
2 years
∆ baseline–4 month ∆ baseline–2 years
End-systolic volume index (ml/m2) Baseline
4 months
2 years
∆ baseline–4 months ∆ baseline–2 years
-11.00 4.88 -16.66 5.63 -6.14 2.90 -12.18 3.86
-8.88 3.16 -11.03 4.21 -14.16 4.78
-2.14 2.68 -4.96 3.33
0.03 0.005 0.04 0.003
0.007 0.01 0.005 0.43
0.14 4.25 2.88 0.15
CFR: coronary flow velocity reserve; HMRI, hyperemic microvascular resistance index; LVEF: left ventricular ejection fraction; LVF: left ventricular function.
Table 4. Multivariate model for the prediction of left ventricular ejection fraction at two years.
Univariable analysis
Variable Coefficient SE p-value
Multivariate analysis
Age ≥ 65 yrs
Male gender
Max CKMB/ULN Number of Q-waves Persistent ST-elevation Myocardial blush grade TIMI post PPCI
CFR baseline IRA
4.50 3.58 0.22 -1.40 3.21 0.67 -0.14 0.04 <0.001 -1.45 0.79 0.07 -3.28 1.50 0.03 -0.19 1.15 0.87
2.45 4.44 0.58 5.84 2.45 0.02
Coefficient SE
-0.10 0.05 -0.58 0.80 -1.37 1.62
2.05 3.04
p-value
0.04 0.47 0.40
0.50
CFR: coronary flow reserve; CKMB, creatine kinase-myocardial band; IRA: infarct related
primary percutaneous coronary intervention; SE: standard error; TIMI: Thrombolysis in Myocardial Infarction; ULN: upper limit of normal.
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artery; PPCI: