Page 122 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax

Chapter 7
Results
The study population is described in Table 1. Mean age was 55±9 years and the left anterior descending artery (73%) was most frequently the IRA. Baseline characteristics of patients who underwent baseline intracoronary measurements did not differ from those who underwent paired measurements.
Table 1. Study population
Characteristic
Age (years)
Male, n (%)
BMI
Risk factors for coronary artery disease
Diabetes mellitus
Hypertension
Family history of coronary heart disease Hypercholesterolemia
Current smoking
Symptom onset to PCI (hrs) Infarct-related artery
Left anterior descending artery Left circumflex artery
Right coronary artery
Reference artery
Left anterior descending artery Left circumflex artery
Right coronary artery
CMR infarct variables
IS (% LV)
Extent of transmurality (% segments >75% infarcted) Presence of MVO
Baseline intracoronary Doppler flow measurements (n=62)
55.2±9.2 49 (79) 26.2±3.4
3 (5)
19 (31) 29 (47) 10 (16) 33 (53) 3.3 (2.4-4.4)
45 (73) 3 (5) 14 (23)
14 (22) 48 (74) 3 (5)
22.8±9.8 21.2±14.0 41 (66)
BMI: body mass index; CMR: cardiac magnetic resonance; IS: infarct size; LV: left ventricle; MVO: microvascular obstruction; PCI: percutaneous coronary intervention
Relation between coronary microvascular function and left ventricular function
During initial coronary flow measurements, CFR in the IRA was significantly lower compared to the reference vessel (2.03±0.53 vs. 2.7±0.5; p<0.001). The observed decreased CFR in the IRA was the result of an increased baseline and decreased hyperaemic average peak velocity (Table 2).
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