Page 79 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek
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Immune cell composition in peripheral blood
  B cells
Cluster 8 Cluster 10 Cluster 11 Cluster 12 Cluster 13
Cluster 20
Antibody profile
CD45RA+
CD45RA+CD11b+CD15+CD16+
CD45RA+CD11b+CD11cdimCCR6dimIgMdim
CD45dimCD38dimCD69+IgMdim
CD45RA+CD3+CD5dimCD7dim CD11bdimCD11cdimCD14dim CD27dimCD69+HLA- DRdim IgM+
CD45RA+CD3+CD4+CD5+CD7+CD20+CD27+CD28dimCD38dimCD127dimCCR6+ CCR7+HLA-DR+IgMdim
    Supplementary table 4.4. Populations within those presented in Supplementary table 4.2 that remained significantly different when tested for all NT1 patients (shortly and longer after disease onset) compared with HLA-matched controls. All clusters that were more frequently found in NT1 patients are green, those more frequently found in HLA-matched controls are red. Statistical testing was performed using two-tailed Mann-Whitney U tests for unpaired samples. To all immune cell clusters that differed with a p<0.01 an asterisk is added. To those clusters that differed with a p<0.001 two asterisks are added.
  Naive CD4+ cells
Cluster 2* Cluster 4* Cluster 9
Memory CD4+ T cells
Cluster 9* Cluster 10* Cluster 13* Cluster 17
Cluster 25*
Cluster 30* Cluster 32* Cluster 33*
CD8+ T cells
Cluster 20*
γδ T cells Cluster 4* Cluster 5
Cluster 7*
Cluster 9* Cluster 14**
T Antibody profile
CD45RA+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CCR7+ CD45RA+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CCR7+ CD45RA+CD3+CD4+CD5+CD7+CD11bdimCD14dimCD11cdimCD127dimCD38dim
Antibody profile
CD45RO+CD3+CD4+CD5+CD7-CD27+CD28+CD127+CD161+CCR6dim
CD45RO+CD3+CD4+CD5+CD7+CD27+CD28+CD127+CD161+CCR6dim
CD45RO+CD3+CD4+CD5+CD7dimCD25+CD27+CD28+CD161dimCCR6dim
CD45RO+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CCR7dimPD1dim
CD45RO+CD3+CD4+CD5+CD7+CD27+CD28dimCD56dimCD127+CD161+CCR6dim KLRG1+
CD45RA+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CD161+CCR7dim CD45RO+CD3+CD4+CD5+CD7dimCD25dimCD28+ CD45RO+CD3+CD4+CD5+CD28+CD161+CCR6dim
Antibody profile
CD45RA+CD3+CD5+CD7+CD8a+CD8b+CD27+CD127dimCCR7dim
Antibody profile
CD45RA+CD3+CD5+CD7+CD25dimCD27+CD28dimCCR6dimCCR7dim
CD45RA+CD3+CD5+CD7+CD8a+CD8b+CD27+CD28+CD103dimCD161+CCR6dim CCR7dimKLRG1+
CD45+CD3+CD5dimCD7dimCD127dimCD161+KLRG1dim CD45RA+CD3+CD5+CD7+CD27+CD28+CD38+CD127dimCCR7dimTCRγδdim CD45RA+CD3+CD5+CD27+CD28+CD38+CCR7dim
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