Page 78 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek

Chapter 4
CD3- CD7+ cells
Cluster 1
Cluster 9 Cluster 10
B cells
Cluster 28 Cluster 30
Antibody profile
CD45RA+CD3-CD7+CD16+CD28+CD56dim CD45RA+CD3-CD7+CD8b+CD11cdimCD16+CD56+CD122dim
CD45RA+CD3-CD7+CD16+CD27dimCD38+CD56+CD122+CD161+N Kp46+
Antibody profile
CD45RA+CD3+CD4+CD5+CD7dimCD8adimCD14dimCD16+CD20+CD38dimCD127dim CD161dimCCR7dim
CD45RA+CD1adimCD4dimCD8adimCD14dimCD16+CD20+CD69dimCD161+CCR6+HLA- DRdimIgM+
Supplementary table 4.3. All immune cell populations within all major immune cell lineages that were significantly different between NT1 patients with recent disease onset compared with those with later disease onset. All clusters that were more frequently found in NT1 patients with recent disease onset are green, those more frequently found in NT1 patients with later disease onset are red. Statistical testing was performed using two-tailed Mann-Whitney U tests for unpaired samples. Except for cluster 35 of the memory CD4+ T cell lineage (p<0.01), all p-values from the analyses shown were between p = 0.01 and p = 0.05.
Naive CD4+ Antibody profile T cells
Cluster 5 CD45RA+CD3+CD4+CD5+CD7+CD11b+CD15dimCD27+CD28dimCD38+CD- 127dimCCR7+
Cluster 16 CD45RA+CD3+CD4+CD5+CD7+CD27+CD28dimCD127+CCR7+ Memory CD4+ T Antibody profile
cells
Cluster 1 Cluster 10 Cluster 35
Cluster 36
CD8+ T cells
None.
CD45RA+CD3+CD4+CD5+CD7+CD27+CD28dimCD127+CD161dimCCR7+ CD45RO+CD3+CD4+CD5+CD7+CD25dimCD27+CD127+CD161+CCR6dim
CD45RA+CD3+CD4+CD5+CD7+CD8adimCD8bdimCD27+CD28dimCD- 38dimCD69dimCD127dimCCR7+IgM+
CD45RO+CD3+CD4+CD5+CD7dimCD8adimCD8bdimCD27+CD28+CD69dimC- D127+CCR7dimIgM+
Antibody profile
γδ T cells Antibody profile
Cluster 18 CD45RA+CD3+CD4dimCD5+CD7+CD8adimCD8b+CD27+CD28dimCD127+CCR7+
Myeloid cells
Cluster 25 Cluster 32
CD3- CD7+ cells
None.
Antibody profile
CD45RA+CD4dimCD11c+CD16+CD20dimCD123dimHLA-DRdim
CD45RA+CD1adimCD4dimCD8adimCD8b+CD16dimCD20+CD69dimCD123dimC CR6+CCR7dimC-kitdimHLA-DR+IgM+
Antibody profile
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