Page 77 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek
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Supplementary table 4.2. All immune cell populations within all major immune cell lineages that were significantly different between NT1 patients with recent disease onset compared with HLA- matched controls. All clusters that were more frequently found in NT1 patients with recent disease onset are green, those more frequently found in HLA-matched controls are red. Statistical testing was performed using two-tailed Mann-Whitney U tests for unpaired samples. Except for cluster 2 and 4 of the naïve CD4+ T cell lineage, cluster 9 and 13 of the memory CD4+ T cell lineage, cluster 14 of the γδ T cell lineage and cluster 9 of the CD3-CD7+ immune cell lineage (p<0.01), all p-values from the analyses shown were between p = 0.01 and p = 0.05.
Naive CD4+ Antibody profile T cells
Immune cell composition in peripheral blood
Cluster 2 Cluster 4 Cluster 9
Memory CD4+ T cells
Cluster 9 Cluster 10 Cluster 13
Cluster 17 Cluster 25
Cluster 30 Cluster 32 Cluster 33 Cluster 36
CD8+ T cells
Cluster 20
γδ T cells Cluster 4 Cluster 5
Cluster 7
Cluster 9 Cluster 14
Myeloid cells
Cluster 13 Cluster 14
CD45RA+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CCR7+ CD45RA+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CCR7+ CD45RA+CD3+CD4+CD5+CD7+CD11bdimCD14dimCD11cdimCD127dimCD38dim
Antibody profile
CD45RO+CD3+CD4+CD5+CD7-CD27+CD28+CD127+CD161+CCR6dim
CD45RO+CD3+CD4+CD5+CD7+CD27+CD28+CD127+CD161+CCR6dim
CD45RO+CD3+CD4+CD5+CD7dimCD25+CD27+CD28+CD161dimCCR6dim
CD45RO+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CCR7dimPD1dim
CD45RO+CD3+CD4+CD5+CD7+CD27+CD28dimCD56dimCD127+CD161+CCR6dim KLRG1+
CD45RA+CD3+CD4+CD5+CD7dimCD27+CD28+CD38+CD161+CCR7dim CD45RO+CD3+CD4+CD5+CD7dimCD25dimCD28+ CD45RO+CD3+CD4+CD5+CD28+CD161+CCR6dim
CD45RO+CD3+CD4+CD5+CD7dimCD8a/bdimCD27+CD28+CD69dimCD127+C- CR7dim
IgM+
Antibody profile
CD45RA+CD3+CD5+CD7+CD8a+CD8b+CD27+CD127dimCCR7dim
Antibody profile
CD45RA+CD3+CD5+CD7+CD25dimCD27+CD28dimCCR6dimCCR7dim
CD45RA+CD3+CD5+CD7+CD8a+CD8b+CD27+CD28+CD103dimCD161+CCR6dim CCR7dimKLRG1+
CD45+CD3+CD5dimCD7dimCD127dimCD161+KLRG1dim
CD45RA+CD3+CD5+CD7+CD27+CD28+CD38+CD127dimCCR7dimTCRγδdim CD45RA+CD3+CD5+CD27+CD28+CD38+CCR7dim
Antibody profile
CD45RO+CD4dimCD11b+CD11c+CD14+CD16+CD38+HLA-DRdim
CD45ROdimCD4dimCD8adimCD11b+CD11c+CD14+CD16+CD38+CD161dim HLA-DRdimIgMdim
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