Page 48 - Strategies for non-invasive managementof high-grade cervical intraepithelial neoplasia - prognostic biomarkers and immunotherapy Margot Maria Koeneman
P. 48

Chapter 2
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Table 1. Candidate biomarkers in the prediction of natural behaviour of CIN
Biomarker group
Biomarker
Assumed role in natural history of CIN
Studied in histologically confirmed CIN?
No of studies on high-grade CIN (incl CIN 2)
Prospective study design?
Study size (n=)
Evaluation according to the PROBE-criteria*
Effect
Host factors
HLA-subtypes
HLA-DRB1*130
Altered antigen presentation efficiency or immune response.
Yes, CIN 1-2
1 (43)
Yes
454
1. + 2. +/- 3. + 4. -
HLA-DRB1*130 expression is associated with decreased disease progression.
Lympho- proliferative response
CD4
More effective immune response.
Yes, CIN 2-3
1 (6)
Yes
162
1. + 2. +/- 3. + 4. -
Higher CD4 cell numbers are associated with increased disease regression.
HLA-DRB1*13
Yes, CIN 1
-
-
-
-
-
HLA*A201
Yes, CIN 2-3
1 (8)
Yes
100
1. + 2. +/- 3. + 4. -
HLA*A201 expression is associated with decreased disease regression.
CD8
Strong T-cell response.
Yes, CIN 2-3
2 (6, 7)
Yes, no
162 , 55
1. +, +/- 2. +/-, +/- 3. +, +
4. -, -
Conflicting results: no effect vs. increased disease regression with higher stromal CD8+ cells numbers.
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