Page 49 - Strategies for non-invasive managementof high-grade cervical intraepithelial neoplasia - prognostic biomarkers and immunotherapy Margot Maria Koeneman

A review of prognostic biomarkers
2
47
Biomarker group
Biomarker CD25
Assumed role in natural history of CIN
Studied in histologically confirmed CIN?
No of studies on high-grade CIN (incl CIN 2)
Prospective study design?
Study Evaluation
size according to the (n=) PROBE-criteria*
Effect
Lympho- proliferative response
Suppression of specific immune response.
Yes, CIN 2-3
2 (6, 7)
Yes,no
162,55 1. +/- 2. +/-
Conflicting results: no effect vs. more disease regression with lower stromal CD 25 cell numbers.
Telomerase amplification
hTERC
Telomere main- tenance has been associated with CIN disease grade in.
Yes, CIN 1-2
1 (49)
Yes
54 1.- 2. +/-
Gain of hTERC is associated with disease progres- sion to CIN 3.
Other markers
HPV antibodies
Increased humoral immune response? Probably no role in natural history of CIN.
Yes, CIN 1-2
1 (53)
Yes
116 1.+ 2.- 3.+ 4.-
No effect of IgG antibodies titres to HPV16, -52, -58 and -6 on disease regression.
CD4/CD25 ratio
Strong T-cell response.
Yes, CIN 2-3
1 (7)
No
55 1. +/- 2. +/-
Higher CD4/ CD25-ratios are associated with increased disease regression.
CD138
Decreased humoral immune response (in favour of cellular immune response).
Yes, CIN 2-3
2 (6, 7)
Yes, no
162 , 55 1. +, +/- 2. +/-, +/-
Conflicting re- sults: no effect vs. increased disease regression with lower stromal CD 138 cells numbers.
3.+ 4. -
3. + 4. -
3. +, + 4. -, -
3.+ 4.-
table continues