Page 91 - Let them speak Towards a patient reported outcome measure set for

PROs used in clinical trials and core outcome sets
symptoms’), and duplicate PROs were merged, resulting in a final set of 14
unique PROs. Table 1 presents the 14 unique PROs. The most commonly
included PROs were cognitive functioning and quality of life.
Integrating and classifying PROs
The 66 different PROs identified in clinical trials, referring to 13 unique
PROs, and the 22 different PROs included in condition-specific COSs,
referring to 14 unique PROs, were integrated. This resulted in a total of
18 unique PROs, with 9 overlapping PROs between those used in clinical
trials and those included in condition-specific COSs (Figure 3). These 18
PROs were classified within the conceptual framework (see Additional file
4). The definition of each PRO was incorporated into the framework when
described alongside the corresponding PRO in the condition-specific COSs.
4
Figure 3. Overlapping PROs used in clinical trials and included in condition-specific COSs.
PROs, patient reported outcomes; COSs, core outcome sets.
89