Page 14 - Epidemiological studies on tuberculosis control and respiratory viruses

Chapter 2
Table 1. Distribution of non-Euro-American and Euro-American lineages over clustered and nonclustered immigrant and native Dutch tuberculosis cases
Nonclustered cases
Immigrants
Resident Resident
<3 yr ≥3 yr Natives
EAI
CAS
Beijing 42 Bovis 5 West African (I,II) 16 With <10 isolates 5 Total 239
Euro-American
Haarlem 55 T specific 64 LAM 68 S 13 Uganda (I,II) 9 New-1 15 TUR 9
X 8 Cameroon 13 Ural 7 With <15 isolates 4 Total 265
Clustered cases
Total study Immigrants Natives population
Lineage
Non-Euro-American
108135199626384 631081511725328
69 37 98 10 26 10 21 2 18 10 6 2 353 105 341
133 166 278 126 151 152 148 61 236 44 30 23 28 4 36 47 8 8 16 5 32 16 16 19 15 10 30 11 6 5 14 2 5 598 459 824
28 274 11 62
2 59
0 23 92 1,130
182 814 134 627 102 615 22 132
4 81
7 85 20 82
21 80
6 74
2 31
0 25 500 2,646
Allowing SLVs to be clustered increased the clustering proportion by 24% and 57% among cases with Euro-American isolates and non-Euro-American isolates, respectively (Table 2). This resulted in a decreased magnitude of association between the risk factors and clustering, in particular for the cases caused by non-Euro-American lineages (Table 2). Similarly, the association between RFLP and VNTR clustering in cases caused by non-Euro-American lineages was reduced compared to that in cases caused by Euro-American lineages. Discrepancy between VNTR and RFLP typing (i.e., clustered by either VNTR or RFLP) was in most cases caused by VNTR clustered and RFLP nonclustered isolates (Table 2). Among 1,130 non-Euro-American isolates, 177
24
No. of isolates