Page 32 - The diagnostic work-up of women with postmenopausal bleeding

Chapter 2
Table 2. Diagnostic accuracy of diagnostic tests in women with PMB
Study
Outcome measure
Cut-off value or device
Sens* (%)
Spec* (%)
LR+*
LR-*
Pre-test probability*
Post-test probability*
Smith-Bindman endometrial cancer
5 mm 96.0 61.0 4 mm 96.0 53.0 3 mm 100.0 38.0 5 mm 95.0 92.0 4 mm 91.0 69.0 3 mm 98.0 62.0 MoM 96.0 50.0 5 mm 91.7 66.1 4 mm n/a n/a 5 mm 95.7 77.5 4 mm n/a n/a 5 mm 90.3 54.0 4 mm 94.8 46.7 3 mm 97.9 35.4
all devices 91.9 99.7
all devices 81.0 98.9 Pipelle n/a n/a
all devices 95.0 99.5 Pipelle 99.6 n/a Pipelle 88.0 98.0
n/a 95.0 88.0 n/a 86.4 99.2 n/a n/a n/a
n/a 96.0 90.0
0.07 0.08 0.00 0.05 0.13 0.03 0.08 0.16 n/a 0.08 n/a 0.18 0.11 0.06
10.0% 1.0% 10.0% 0.8% 10.0% 0.0% 40.0% 3.5% 40.0% 8.0% 40.0% 2.11% 10.0% 0.9% 10.0% 2.5% n/a n/a 40.0% 5.1% n/a n/a 10.0% 2.0% 10.0% 1.2% 10.0% 0.7%
4.5% 81.8%
14.3% 66.7% 14.3% 62.3%
10.0% 95.5% n/a n/a 14.3% 88.0% n/a n/a 3.9% 71.8% 10.0% 64.8%
61.0% 93.0%
Tabor Gupta ‡
Timmermans
Clark Dijkhuizen
de Kroon Clark
van Dongen¥
endometrial cancer endometrial cancer endometrial disease endometrial disease endometrial disease endometrial cancer endometrial cancer endometrial cancer endometrial disease endometrial disease endometrial cancer endometrial cancer endometrial cancer endometrial cancer¥ hyperplasia
hyperplasia endometrial cancer endometrial cancer
hyperplasia abnormal cavity endometrial cancer ¥ endometrial cancer (PMP)
abnormal cavity
95.1
73.6 n/a
190.0 n/a 44.0 n/a 60.9 38.3
7.9
n/a
n/a = not applicable or not available; MoM = multiples of the median; PMP = postmenopausal.
* Bold when extracted from article, normal when calculated, italic when extracted from literature. ‡ For the cut-off value of 4 mm, no studies included with good quality.
¥ Pre- and postmenopausal women.
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hysteroscopy hysteroscopy SIS sampling sampling TVS TVS TVS TVS Subject