Page 31 - The diagnostic work-up of women with postmenopausal bleeding

Diagnostic evaluation
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Table 1. Studies about accuracy of diagnostic tests in women with PMB
Author
Year Type of study
Studies (N) Total PMP Total
Patients (N) PMP HRT
Subject
Failure/ inadequate
Reference test
Smith-Bindman et al.
1998 systematic review meta-analysis
35 35 9 9 57 4 11 11 6 2 39 7 24 n/a
5892 5892 3813 2700 7270 464 2896 2896 881 220 7814 760 2278 268
8.0% 0.0% 1.3% n/a n/a n/a <5% 4.3% <5%
TVS TVS TVS TVS biopsy biopsy SIS hysteroscopy hysteroscopy
0% 0% n/a n/a n/a n/a n/a n/a 4% 2% 0-41% 0-54% 7% n/a 3.6% 3.4% 3.2% 4.4%
endometrial sampling or D&C or hysterectomy D&C or endometrial sampling
Tabor et al.
Gupta et al. Timmermans et al. Clark et al. Dijkhuizen et al. de Kroon et al. Clark et al.
van Dongen et al.
2002 systematic review meta-analysis
n/a = not applicable
PMP = postmenopausal women
* pre- and postmenopausal women
2002 systematic review meta-analysis
endometrial sampling or D&C or hysterectomy
2010 syst review
IPD meta-analysis
histology (different methods)
2001 systematic review meta-analysis
histology (by inpatient sampling)
2000 systematic review meta-analysis
D&C or hysteroscopy or hysterectomy
2003 systematic review meta-analysis
hysteroscopy or hysterectomy
2002 systematic review meta-analysis
65 2 26346 1948
histology
(different methods)
2007 systematic review meta-analysis
17 5
4208 306
histology
(different methods)
Overall PMP