Page 294 - Prevention and Treatment of Incisional Hernia- New Techniques and Materials

Chapter 14
(P = 0.128). Permacol was incorporated median 21% (IQR, 3 to 39) at 90 days, decreasing to 6% (IQR, 0 to 31) at 180 days (P = 0.320). At both time points, incorporation was not di erent between Strattice and Permacol (P = 0.513 and P 5.506). There was no di erence in incorporation between crosslinked and non-crosslinked meshes (P = 0.537).
Figure 4. Comparison of the percentage of each mesh covered with adhesions after 90 and 180 days’ follow-up. Values represented as median (interquartile range). Strattice has signi cant lower adhesion formation than Surgisis, Permacol and Colla-MendFM at 90 and 180 days, *P < 0.05.
Adhesions
In the control group, 6 of 15 rats (40%) showed visceral adhesions to the midline scar with a maximum Zühlke score of 2. Adhesion coverage per mesh group is depicted in Figure 4. At 90 and 180 days, median 100% of the original implantation site of the Surgisis was covered with adhesions (90 days IQR, 76% to 100%; 180 days IQR, 100% to 100%). CollaMendFM was covered with median 100% adhesions at 90 and 180 days (90 days IQR, 95% to 100%; 180 days IQR, 100% to 100%). Strattice had little adhesion formation to the mesh at 90 and 180 days (both time points median 5%; IQR, 5% to 10%), which was signi cantly lower than the other meshes (P < 0.038). At 90 days, median 68% (IQR, 48% to 93%) of mesh surface of Permacol was covered by adhesions and at 180 days, median 42% (IQR 13% to 100%). Alteration in adhesion coverage between 90 and 180 days in all mesh groups was not signi cantly di erent (P > 0.356).
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