Page 35 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

Table 2.1.4. Characteristics of women with full follow-up data and lost-to-follow-up with
regard to proteinuria measurements
Complete Data n=121
31 (21-42)
5 (0-62) 170 (130-250)
110 (90-170) 3.1 (0.3-27.2) 82 (45-394)
Our results show that hypertension and proteinuria can resolve during the first two years following a preeclamptic pregnancy. Of all women that had hypertension at 3 months postpartum, 50% resolved within two years postpartum. So these women could not have had true chronic hypertension and would have been misclassified by current definition. Furthermore, a surprisingly 14% still had proteinuria at three months postpartum. Of these women, 85% resolved within two years postpartum. Clinical features that were associated with a longer time to resolution were higher maximal blood pressure and higher maximal level of proteinuria during pregnancy and a longer time interval between diagnosis and delivery.
Previous longitudinal studies of resolution of hypertension are limited in follow-up time and mainly focus on the differences of resolution between the types of hypertensive disorder in pregnancy84-87. The longest previous longitudinal study on resolution of hypertension had a follow-up time of 50 days
Gestational age at diagnosis (weeks) Prolongation of preeclampsia (days) Maximal systolic blood pressure during preeclampsia (mmHg)
Maximal diastolic blood pressure during preeclampsia (mmHg)
Maximal level of proteinuria during preeclampsia (gr/24h)
31 (25-41) 0.46 11 (0-50) 0.11 170 (130-280) 0.73
110 (90-160) 0.80 6.9 (0.3-31.4) 0.001 83 (45-626) 0.72
Maximal level of creatinine during
preeclampsia (mmol/l)
Values are presented as median(range) and compared using Mann-Whitney tests.
DISCUSSION
2.1 Resolution of hypertension and proteinuria| 33
Lost-to-follow-up n=84
p-value