Page 34 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

32 | Part 2 Cardiovascular Health
Table 2.1.3. Coefficients of the AFT-model
Resolution of hypertension Constant
Maximum systolic blood pressure (mmHg) Maximum diastolic blood pressure (mmHg) Prolongation of preeclampsia (days)
Resolution of proteinuria Constant
Maximum level of proteinuria (gr/24h)
Values are presented as median(range) and compared using Mann-Whitney tests.
Proteinuria
Coefficient (95%-CI)
-10.76 (-14.21- -7.16) 0.05 (0.03-0.07) 0.03 (0.00-0.07) 0.04 (0.01-0.06)
-0.53 (-0.95-0.10)
p-value
<0.001 0.044 0.001
<0.001
0.15 (0.11-0.19)
For 121 women complete proteinuria data was available: for all those women resolution of proteinuria was identified. The remaining 84 women were lost to follow-up before resolution of proteinuria. Table 2.1.4 shows the comparison between these two groups, showing the latter group having had higher levels of maximal proteinuria during preeclampsia.
Figure 2.1.5 shows the resolution curve for proteinuria with 95% confidence interval. At discharge after delivery 65% of women still had proteinuria. At six weeks postpartum in 21%, and at three months postpartum in 14% of women proteinuria was present. Finally, at two years postpartum 2% had persistent proteinuria. No difference was observed in normalization between primiparous and multiparous women. In the AFT-model, higher maximum level of proteinuria during preeclampsia increased resolution time (p<0.001). Figure 2.1.6 shows the effect on the rate of resolution of proteinuria when this variable changes. The coefficients for the corresponding AFT-model are presented in table 2.1.3. Resolution time of proteinuria was not significantly correlated with the maximal systolic and diastolic blood pressure during preeclampsia, gestational age at onset of preeclampsia and time interval between diagnosis and delivery.