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                                    ContentsChapter 1 Introduction and outline of this thesis 9Part one Pancreatic cancer 23Chapter 2 Phase I clinical trial to determine the feasibility and maximum tolerated dose of panitumumab to standard gemcitabine-based chemoradiation in locally advanced pancreatic cancer25Chapter 3 Reintroduction of palliative intent FOLFIRINOX chemotherapy in a real world pancreatic cancer cohort45Part two Esophageal and gastric cancer 61Chapter 4 Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer63Chapter 5 The prognostic impact of circulating miRNAs in patients with advanced%u00a0esophagogastric%u00a0cancer%u00a0during%u00a0palliative chemotherapy85Chapter 6 Summarizing discussion and future perspectives 107Addendum Dutch summary (Nederlandse samenvatting)List of publications Curriculum VitaeDankwoord124129134136
                                
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