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Chapter 9190be a non-inferiority study to compare patient-specific instrumented ACL reconstruction to the current gold standard in terms of clinical outcomes (like objective knee laxity, subjective knee function and hop test battery outcome) and whether it leads to more natural knee kinematics. Another topic of future research is whether patient-specific ACL reconstruction can in fact lead to better return-to-sports rates. Also, a future topic that needs to be addressed is whether the added costs of patient-specific instrumentation outweigh potential long-term benefits such as reduced re-injuries and development of osteoarthritis.All in all, ACL reconstruction is only one item in the toolbox when treating a patient with ACL injury aiming to return to sports. It should be recognised that a one-size-fits-all approach is no longer appropriate in the treatment of ACL injured patients, but rather a patient-specific approach is needed along all five R’s of the ACL: from rupture, rotation, reconstruction and rehabilitation towards return to sports.Mark Zee.indd 190 03-01-2024 08:56