Page 130 - ADULT-ONSET ASTHMA PREDICTORS OF CLINICAL COURSE AND SEVERITY

ADULT-ONSET ASTHMA – PREDICTORS OF CLINICAL COURSE AND SEVERITY
Table 4. Odds ratios for factors potentially associated with a deterioration in GINA score.
Covariate
FEV1/FVC <95%
> 20 pack year
Sputum neutrophils >64%
FEV1/FVC per 10% lower
BMI > 30
Every 10 pack year smoked
Nasal polyposis, yes
Age > 50 yr
CRS, yes
Atopy, yes
Female
Exhaled NO
Sputum eosinophils >2%
Univariate odds ratios with 95% confidence intervals are given. Significant odds ratios are printed in boldface.
Table 5. Multivariate odds ratios for factors associated with a deterioration in GINA score.
Odds ratio
95% CI 1.30 - 11.98 1.22 - 10.76
3.9 3.6 2.5 1.6 1.6 1.5 1.4 1.3 1.2 0.8 0.6 0.6 0.4
0.60 - 9.98 1.03 - 2.56 0.56 - 4.52 1.10 - 2.02 0.40 - 4.59 0.48 - 3.68 0.42 - 3.35 0.28 - 2.24 0.23 - 1.80 0.19 - 1.79 0.08 - 2.00
Covariate
10 pack year
FEV1/FVC per 10% lower
FEV1/FVC <95% 10 pack year
Odds ratio 1.4
1.4
Odds ratio 3.1
1.4
95% C.I. 1.02 - 1.91 0.88 - 2.36
95% C.I. 0.99 - 9.92 1.01 - 1.89
Odds ratios with 95% confidence intervals are given. Two models are selected with significant variables from Table 4.
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