Page 129 - ADULT-ONSET ASTHMA PREDICTORS OF CLINICAL COURSE AND SEVERITY
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PREDICTORS FOR THE DEVELOPMENT OF PROGRESSIVE SEVERITY IN NEW-ONSET ADULT ASTHMA
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Table 3. Longitudinal changes; comparison between baseline and 2 years.
BMI, kg/m^2
Fluticasone equivalent μg ACQ score
GINA score
pb FEV1 % predicted
pb FEV1/FVC % predicted Exhaled NO, ppb
Blood neutrophils, x10^9/L Blood eosinophils, x10^9/L
0.492 27.2 <0.001 250 0.049 1.13 <0.001 2.5 0.302 101 0.245 96 0.326 19.6 0.256 3.8 0.222 0.16
2 years 27.3 250 1.05 2.5 103
p-value Baseline 0.716 29.4 0.181 500 0.217 1.52 0.322 3
2 years 29.7 250 1.05
p-value 0.974 <0.001 <0.001 <0.001 0.007 0.100 0.513 0.363 0.181
Deterioration (n=17) Baseline 2 years 28.7 28.9 250 500 1.15 1.55
No change (n=58) p-value Baseline
Improvement (n=53)
2 4
93 95 90 87 17.4 25.6 4.2 4.6 0.17 0.15
94 21.3 3.7 0.17
0.149 102 0.084 97 0.106 22.2 0.842 3.7 0.350 0.16
2 105 96 23.0 3.5 0.17
Significant p-values are printed in boldface. pb: post-bronchodilator. ppb: parts per billion.
