Page 46 - Fluorescence-guided cancer surgery

44
Chapter 3
RESULTS
A total of 24 patients were included in this study. Patient and tumor characteristics are detailed in Table 1. Mean patient age was 60 years (range 44 - 82 years); 21 patients were planned for BCS, 3 patients received an MRM. Histopathological analysis showed 14 patients with in ltrating ductal adenocarcinoma, 4 patients with in ltrating lobular adenocarcinoma, 3 patients with ductal carcinoma in situ, 1 patient with a primary mucoepidermoid carcinoma, 1 patient with a mucinous adenocarcinoma, and in 1 patient, no tumor was found in the resected specimen even though a preoperative biopsy showed in ltrating adenocarcinoma. Although patients were not assigned to a speci c administration group by randomization, groups were comparable as no signi cant di erences in patient or tumor characteristics were found (Table 1). All patients received preoperative ultrasound, and 9 patients also underwent preoperative MRI scan.
In 20 out of 24 patients (83%), breast tumors (carcinoma in N=21 and ductal carcinoma in situ in N=3) were identi ed in the resection specimen with NIR uorescence imaging after bisection in the Pathology department. Tumors were identi ed as a bright uorescent spot in the sliced specimen (Figure 1).
Table 2 shows patient and tumor characteristics related to detectability of the tumor. Patients with non-detectable tumors were signi cantly older (mean age 68 years old versus 58 years old; P=0.03). Both in ltrating ductal type adenocarcinoma and in ltrating lobular type adenocarcinoma were detectable. In patients with mucinous adenocarcinoma or primary mucoepidermoid carcinoma, no uorescent tumor was found. No signi cant relation was found regarding receptor status or tumor grade.