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General introduction and outline of this thesis115to assess OHRQoL in patients who underwent coronectomy for an impacted mandibular third molar.Next, in Chapter 7, we investigated the effects of periapical surgery on pain and OHRQoL during the first post-operative week. Finally, we carried out a longitudinal study, over at least one year post-operatively, to investigate the quality of life of patients who underwent orthognathic surgery (Chapter 8). All of our findings are summarized in the general discussion in Chapter 9, where we also provide some guidance for future studies. Chapter 10 and 11 presents the general summary of this thesis, in both English and Dutch.