Page 58 - Sentinel lymph node biopsy in oral cavity cancer - Inne J. den Toom

Chapter 3 Table 2. Sensitivity and negative predictive value SLNB END % (95% CI) % (95% CI) 84 (73 to 87) 93 (91 to 95) 70 (65 to 85) 94 (91 to 96) 90 (77 to 96) 94 (83 to 96) 92 (44 to 80) 97 (85 to 94) 80 (78 to 92) 92 (92 to 97) p-value 0.612 1.000 0.637 1.000 0.776 0.565 0.006 0.057 0.315 0.250 Overall pT1* pT2* FOM** Other locations** Sensitivity 81 NPV 93 Sensitivity 76 NPV 94 Sensitivity 88 NPV 91 Sensitivity 63 NPV 90 Sensitivity 86 NPV 95 (76 to 90) (90 to 95) (51 to 84) (90 to 96) (82 to 96) (88 to 97) (79 to 98) (91 to 99) (70 to 88) (88 to 95) Abbreviations: SLNB, sentinel lymph node biopsy, END, elective neck dissection ; FOM, floor of mouth; NPV, negative predictive value * pT1 versus pT2 witin the SLNB group: sensitivity p = 0.075 and NPV p = 0.415 * pT1 versus pT2 witin the END group: sensitivity p = 0.010 and NPV p = 1.000 ** FOM versus Other locations within the SLNB group: sensitivity p = 0.008 and NPV p = 0.113 ** FOM versus Other locations within the END group: sensitivity p = 0.114 and NPV p = 0.130 to the END others (93% vs. 88%, p = 0.046). Only the difference between SLNB FOM compared to END others remains significant after the Bonferroni correction (p = 0.017). In the DSS analysis with the END and SLNB groups divided for TP, TN and FN (Figure 2C), the SLNB TN had the longest DSS (97%) and was only not significantly different compared to the END TN (95%). END TN and SLNB TN had significant longer DSS compared to the other groups (Figure 2C). Regarding the FN cases, the END FN (23%) had the shortest DSS and was significant different compared to all other groups. The SLNB FN (85%) had a comparable DSS compared to the SLNB TP (86%). After the Bonferroni correction, the differences between SLNB FN (85%) and END TN (95%) and between SLNB TP (86%) with END TN (95%) were not significant anymore. The DSS analysis for SLNB staged patients with a FOM tumour and divided by TP, TN and FN (Figure 2D), showed the shortest DSS for SLNB FN patients (91%), however no significant differences were found between these three groups. 56